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Title: Characterization of a unique borreliacidal epitope on the outer surface protein C of Borrelia burgdorferi.
identifier: 1326963
description:
epitope description:TFTNKLKEKHTDLGK
antigen name:Outer surface protein C
host organism:Mus musculus BALB/c
antibody name:16.22
aggregation:
instance of dataset
availability:
available
primaryPublications: 16965353
authorizations:
registration not required
accessURL: http://www.iedb.org/reference/1002179
landingPage: http://www.iedb.org/assay/1326963
type:
Literature
publicationVenue:
FEMS Immunol Med Microbiol
dates:
2006
study type: b cell assays
subject species: Borrelia burgdorferi B31
fullName:
Xiaohua Yang
Yang Li
John J Dunn
Benjamin J Luft
method:
biological activity
name:
Characterization of a unique borreliacidal epitope on the outer surface protein C of Borrelia burgdorferi.
description:
The purified epitope-specific mAb 16.22 was incubated with B. burgdorferi B31 for 24 hours, and a significant fraction (90%) of the organisms were no longer viable. MAb 16.22 was found to effectively inhibit B31-OspC-A-type spirochete growth and morphologically eliminated the motility and disrupt the spirochetes using both the microscopic and colormetric assays.

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