A mutation in the envelope protein fusion loop attenuates mouse neuroinvasiveness of the NY99 strain of West Nile virus.

Title:

A mutation in the envelope protein fusion loop attenuates mouse neuroinvasiveness of the NY99 strain of West Nile virus.

identifier:	1326977
description:	epitope description:L107 antigen name:Genome polyprotein host organism:Mus musculus antibody name:3D9
aggregation:	instance of dataset
availability:	available
primaryPublications:	16806383

study type:	b cell assays
subject species:	West Nile virus strain 385-99

fullName:	Shuliu Zhang Li Li Sara E Woodson Claire Y-H Huang Richard M Kinney Alan D T Barrett David W C Beasley

method:	western blot

name:	A mutation in the envelope protein fusion loop attenuates mouse neuroinvasiveness of the NY99 strain of West Nile virus.
description:	The antibody failed to bind when the epitope was mutated to L107F. It was found that the mutated virus had an LD50 of >1000 pfu, in contrast to the wild type virus with an LD50 of 1.3 pfu.

name:	iedb
homePage:	http://www.iedb.org

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