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Title: Glycosylation of immunodominant linear epitopes in the carboxy-terminal region of the caprine arthritis-encephalitis virus surface envelope enhances vaccine-induced type-specific and cross-reactive neutralizing antibody responses.
identifier: 1327169
description:
epitope description:RRKRELSHTRKKR
antigen name:envelope polyprotein
host organism:Capra hircus Saanen
aggregation:
instance of dataset
availability:
available
primaryPublications: 15308714
authorizations:
registration not required
accessURL: http://www.iedb.org/reference/1002186
landingPage: http://www.iedb.org/assay/1327169
type:
Literature
publicationVenue:
J Virol
dates:
2004
study type: b cell assays
subject species: Caprine arthritis encephalitis virus G63
fullName:
J D Trujillo
N M Kumpula-McWhirter
K J Hö
tzel
M Gonzalez
W P Cheevers
method:
ELISA
name:
Glycosylation of immunodominant linear epitopes in the carboxy-terminal region of the caprine arthritis-encephalitis virus surface envelope enhances vaccine-induced type-specific and cross-reactive neutralizing antibody responses.
description:
Sera from goats infected with caprine arthritis encephalitis virus envelope glycoprotein bound the epitope by ELISA. Mutation of the immunizing protein at residues R539S and E542N to create N-linked glycosylation sites resulted in a lower antibody titer to the epitope.

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