Mimotopes of the hyper variable region 1 of the hepatitis C virus induce cross-reactive antibodies directed against discontinuous epitopes.

Title:

Mimotopes of the hyper variable region 1 of the hepatitis C virus induce cross-reactive antibodies directed against discontinuous epitopes.

identifier:	1330085
description:	epitope description:QTHTTGGVVGHATSGLTSLFSPGPSQK host organism:Oryctolagus cuniculus New Zealand White
aggregation:	instance of dataset
availability:	available
primaryPublications:	11741698

study type:	b cell assays
subject species:

fullName:	R Roccasecca A Folgori B B Ercole G Puntoriero A Lahm S Zucchelli R M Pezzanera G Galfre A Tramontano M U Mondelli A Pessi A Nicosia R Cortese A Meola

method:	ELISA

name:	Mimotopes of the hyper variable region 1 of the hepatitis C virus induce cross-reactive antibodies directed against discontinuous epitopes.
description:	Amino acids at position 3, 11, 18, 21, 22 and 24 within the 27-mer peptide discriminated frequency of cross-reactivity with HCV patient sera. The sequence was from cited reference (S. Zucchelli et al, Hepatology, (2001) 33:692-703) The epitope specific antisera cross-reacted with 42 out of 43 HCV hyper variable region 1 sequences (27-mer) chosen from 234 natural isolates by the Sequencespace algorithm with equally distant position as representatives of the vial variability. The epitope-specific antisera also reacted with 7 out of 10 mimotopes from phage display library inserted in E2 glycoprotein by ELISA.

name:	iedb
homePage:	http://www.iedb.org

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