Immunological Data Discovery Index
Immunological Data Discovery Index
| authorizations: |
registration not required
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| accessURL: |
http://www.iedb.org/reference/1002223 |
| landingPage: |
http://www.iedb.org/assay/1330449 |
| type: |
Literature
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| publicationVenue: |
J Biol Chem
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| dates: |
2005
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| study type: | b cell assays |
| subject species: | Plasmodium falciparum |
| fullName: |
Dharmendar Rathore
Rana Nagarkatti
Dewal Jani
Rana Chattopadhyay
Patricia de la Vega
Sanjai Kumar
Thomas F McCutchan
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| method: |
ELISA
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| name: |
An immunologically cryptic epitope of Plasmodium falciparum circumsporozoite protein facilitates liver cell recognition and induces protective antibodies that block liver cell invasion.
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| description: |
In further experiments designed to investigate whether polymorphisms can attribute to a change in recognition of the peptide, two variant peptides were synthesized where Lys12 of the peptide was substituted by an asparagine and threonine. Both of the variants showed a 40% decrease inrecognition in comparison with the native sequence, suggesting that these changes in the field isolates are mostlikely associated with immune evasion. Also, deletions of as few as 3 amino acids from either end led to a 50% decrease in the recognition of the epitope by the antibodies.
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| name: |
iedb
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| homePage: |
http://www.iedb.org |
