An immunologically cryptic epitope of Plasmodium falciparum circumsporozoite protein facilitates liver cell recognition and induces protective antibodies that block liver cell invasion.

Title:

An immunologically cryptic epitope of Plasmodium falciparum circumsporozoite protein facilitates liver cell recognition and induces protective antibodies that block liver cell invasion.

Dataset

identifier:	1330659
description:	epitope description:NEDNEKLRKPKHKKLKQPG antigen name:Circumsporozoite (CS) protein host organism:Mus musculus
aggregation:	instance of dataset
availability:	available
primaryPublications:	15781464

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1002223
landingPage:	http://www.iedb.org/assay/1330659

Publication

type:	Literature
publicationVenue:	J Biol Chem
dates:	2005

Dimension

study type:	b cell assays
subject species:	Plasmodium falciparum

Person

fullName:	Dharmendar Rathore Rana Nagarkatti Dewal Jani Rana Chattopadhyay Patricia de la Vega Sanjai Kumar Thomas F McCutchan

Data Type

method:	biological activity

Study

name:	An immunologically cryptic epitope of Plasmodium falciparum circumsporozoite protein facilitates liver cell recognition and induces protective antibodies that block liver cell invasion.
description:	Serum was evaluated for the recognition of circumsporozoite protein expressed on P. falciparum (NF54 strain), and the antibodies recognized circumsporozoite protein expressed on sporozoite surface. The antibodies also were successful in preventing the invasion of liver cells by live P. falciparum sporozoites in a dose-dependent manner.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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