Placental malaria diminishes development of antibody responses to Plasmodium falciparum epitopes in infants residing in an area of western Kenya where P. falciparum is endemic.

Title:

Placental malaria diminishes development of antibody responses to Plasmodium falciparum epitopes in infants residing in an area of western Kenya where P. falciparum is endemic.

Dataset

identifier:	1330756
description:	epitope description:GQHGHMHG antigen name:Other Plasmodium falciparum (malaria parasite P. falciparum) protein host organism:Homo sapiens
aggregation:	instance of dataset
availability:	available
primaryPublications:	15753250

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1002234
landingPage:	http://www.iedb.org/assay/1330756

Publication

type:	Literature
publicationVenue:	Clin Diagn Lab Immunol
dates:	2005

Dimension

study type:	b cell assays
subject species:	Plasmodium falciparum

Person

fullName:	Phillip Cullison Bonner Zhiyong Zhou Lisa B Mirel John G Ayisi Ya Ping Shi Anna M van Eijk Juliana A Otieno Bernard L Nahlen Richard W Steketee Venkatachalam Udhayakumar

Data Type

method:	ELISA

Study

name:	Placental malaria diminishes development of antibody responses to Plasmodium falciparum epitopes in infants residing in an area of western Kenya where P. falciparum is endemic.
description:	To determine the effect of placental malaria (PM) infection on the development of antibody responses tomalaria in infants, IgG levels to seven different Plasmodium falciparum epitopes were measured using plasma samples collected at monthly intervals from infants born to mothers with and without PM. Overall, PM was associated with diminished antibody levels to all of the epitopes tested, especially with infants aged 4 to 12 months.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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