Immunological Data Discovery Index
Immunological Data Discovery Index
| authorizations: |
registration not required
|
| accessURL: |
http://www.iedb.org/reference/1002010 |
| landingPage: |
http://www.iedb.org/assay/1330776 |
| type: |
Literature
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| publicationVenue: |
Hepatology
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| dates: |
1999
|
| study type: | b cell assays |
| subject species: | Hepatitis C virus subtype 1b |
| fullName: |
M U Mondelli
A Cerino
A Lisa
S Brambilla
L Segagni
A Cividini
M Bissolati
G Missale
G Bellati
A Meola
B Bruniercole
A Nicosia
G Galfrè
E Silini
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| method: |
antigen inhibition
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| name: |
Antibody responses to hepatitis C virus hypervariable region 1: evidence for cross-reactivity and immune-mediated sequence variation.
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| description: |
The sequence is from hypervariable region 1 (HVR1
amino acids 391-406) of the HCV E2 protein from the dominant sequence isolated from HCV-infected patient C at baseline.
The epitope sequence was derived from a patient with chronic HCV type 1b infection after 1-year follow-up. The patient's sera reacted with the epitope and peptide P20, the sequence of which was derived from another infected patient (genotyep 2 a/c) and shares 4 positions. Binding of the patient's sera to the epitope was inhibited 24.9% by absorption of the sera with immobilized peptide P20. The authors conclude that the sera contain variant-specific and cross-reactive antibodies. Cross-reactivity was not related to the number of homologous residues between peptides.
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| name: |
iedb
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| homePage: |
http://www.iedb.org |
