Immunological Data Discovery Index
Immunological Data Discovery Index
| authorizations: |
registration not required
|
| accessURL: |
http://www.iedb.org/reference/1002010 |
| landingPage: |
http://www.iedb.org/assay/1330860 |
| type: |
Literature
|
| publicationVenue: |
Hepatology
|
| dates: |
1999
|
| study type: | b cell assays |
| subject species: | Hepatitis C virus subtype 1b |
| fullName: |
M U Mondelli
A Cerino
A Lisa
S Brambilla
L Segagni
A Cividini
M Bissolati
G Missale
G Bellati
A Meola
B Bruniercole
A Nicosia
G Galfrè
E Silini
|
| method: |
ELISA
|
| name: |
Antibody responses to hepatitis C virus hypervariable region 1: evidence for cross-reactivity and immune-mediated sequence variation.
|
| description: |
The sequence is from hypervariable region 1 (HVR1
amino acids 391-406) of the HCV E2 protein from the dominant sequence isolated from HCV-infected patient C at baseline.
Sera was collected at baseline (t0) and after a 1-year follow-up (t12) from 7 patients with chronic HCV type 1b infection. The t0 and t12 sera from the patient harboring the epitope sequence and 3 other patients' sera reacted with the epitope. In total, the epitope was recognized by 8 of 14 sera. The predominant IgG subclass was IgG1 in the patient sera analyzed. The authors conclude that sera from 6 of 7 patients displayed considerable cross-reactivity for a variable number of HVR1 sequences in addition to the patient-derived sequence.
|
| name: |
iedb
|
| homePage: |
http://www.iedb.org |
