Immunological Data Discovery Index
Immunological Data Discovery Index
| authorizations: |
registration not required
|
| accessURL: |
http://www.iedb.org/reference/1002010 |
| landingPage: |
http://www.iedb.org/assay/1332572 |
| type: |
Literature
|
| publicationVenue: |
Hepatology
|
| dates: |
1999
|
| study type: | b cell assays |
| subject species: | Hepatitis C virus genotype 2 |
| fullName: |
M U Mondelli
A Cerino
A Lisa
S Brambilla
L Segagni
A Cividini
M Bissolati
G Missale
G Bellati
A Meola
B Bruniercole
A Nicosia
G Galfrè
E Silini
|
| method: |
ELISA
|
| name: |
Antibody responses to hepatitis C virus hypervariable region 1: evidence for cross-reactivity and immune-mediated sequence variation.
|
| description: |
The epitope is derived from isolates of patients with HCV genotype 2 a/c.
Sera was collected at baseline (t0) and after a 1-year follow-up (t12) from 5 patients with chronic HCV type 2a/c infection. The t0 and t12 sera from the patient harboring the epitope sequence reacted very weakly and two other patients' t0 and/or t12 sera reacted with the epitope. In total, the epitope was recognized by 5 of 10 sera. The predominant IgG subclass was IgG1 in the patient sera analyzed. The authors conclude that patient sera displayed cross-reactivity for a variable number of HVR1 sequences in addition to the patient-derived sequences.
|
| name: |
iedb
|
| homePage: |
http://www.iedb.org |
