Immunological Data Discovery Index
Immunological Data Discovery Index
| authorizations: |
registration not required
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| accessURL: |
http://www.iedb.org/reference/1002010 |
| landingPage: |
http://www.iedb.org/assay/1332583 |
| type: |
Literature
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| publicationVenue: |
Hepatology
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| dates: |
1999
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| study type: | b cell assays |
| subject species: | Hepatitis C virus genotype 2 |
| fullName: |
M U Mondelli
A Cerino
A Lisa
S Brambilla
L Segagni
A Cividini
M Bissolati
G Missale
G Bellati
A Meola
B Bruniercole
A Nicosia
G Galfrè
E Silini
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| method: |
antigen inhibition
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| name: |
Antibody responses to hepatitis C virus hypervariable region 1: evidence for cross-reactivity and immune-mediated sequence variation.
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| description: |
The epitope is derived from isolates of patients with HCV genotype 2 a/c.
A patient's sera cross-reacted with the epitope and with peptide P4, the sequence of which was derived from the sera donor and shares 5 positions. Binding of the patient's sera to the epitope was inhibited 66.7% by absorption of the sera with immobilized peptide P4. Binding to the epitope was inhibited 91% by absorption of the sera with immobilized epitope. The authors conclude that the sera contain variant-specific and cross-reactive antibodies. Cross-reactivity was not related to the number of homologous residues between peptides.
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| name: |
iedb
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| homePage: |
http://www.iedb.org |
