Chimeric monoclonal antibodies to hypervariable region 1 of hepatitis C virus. | ImmuneData Discovery Index

Immunological Data Discovery Index

Immunological Data Discovery Index

Title:

Chimeric monoclonal antibodies to hypervariable region 1 of hepatitis C virus.

Dataset

identifier:	1329749
description:	epitope description:KGLNGLFDLGPKQKI antigen name:Genome polyprotein host organism:Mus musculus BALB/c antibody name:mAb 15H4, human (constant region )-mouse (CDR) chimera
aggregation:	instance of dataset
availability:	available
primaryPublications:	15914849

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1002205
landingPage:	http://www.iedb.org/assay/1329749

Publication

type:	Literature
publicationVenue:	J Gen Virol
dates:	2005

Dimension

study type:	b cell assays
subject species:	Hepatitis C virus

Person

fullName:	Chengyao Li Jean-Pierre Allain

Data Type

method:	antigen inhibition

Study

name:	Chimeric monoclonal antibodies to hypervariable region 1 of hepatitis C virus.
description:	This 15-mer peptide was derived from the HVR1 of the HCV polyprotein (strain MH2). Competitive inhibition of HVR1-specific human-mouse chimeric antibody (15H4) was not demonstrated using this 9-mer peptide, showing that the recognition of mAb 15H4 is not based on the conserved G--Q motif. 15H4 reacted only with the MH2 15-mer peptide.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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