Chimeric monoclonal antibodies to hypervariable region 1 of hepatitis C virus. | ImmuneData Discovery Index

Immunological Data Discovery Index

Immunological Data Discovery Index

Title:

Chimeric monoclonal antibodies to hypervariable region 1 of hepatitis C virus.

Dataset

identifier:	1329805
description:	epitope description:TYSFVSLLSPGAKQN antigen name:Genome polyprotein host organism:Mus musculus BALB/c antibody name:cAbs 2P24, 15H4 and mAbs 2P24, 15h4
aggregation:	instance of dataset
availability:	available
primaryPublications:	15914849

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1002205
landingPage:	http://www.iedb.org/assay/1329805

Publication

type:	Literature
publicationVenue:	J Gen Virol
dates:	2005

Dimension

study type:	b cell assays
subject species:	Hepatitis C virus

Person

fullName:	Chengyao Li Jean-Pierre Allain

Data Type

method:	ELISA

Study

name:	Chimeric monoclonal antibodies to hypervariable region 1 of hepatitis C virus.
description:	This 15-mer peptide was derived from the HVR1 of the HCV polyprotein (strain G3959). Thirty-seven HVR1 peptides were tested against HVR1-specific chimeric antibodies (cAb) and standard mAbs to determine the cross-reactivity and specificity of the cAbs. The cAbs and mAbs (2P24 and 15H4) reacted with 32 of 37 HVR1 peptides. Reactivity for cAbs and mAbs were similar. In separate experiments, both antibodies were also found to capture HCV from the plasma of patients and inhibit the binding of HCV to Molt-4 cells.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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