Chimeric monoclonal antibodies to hypervariable region 1 of hepatitis C virus. | ImmuneData Discovery Index

Immunological Data Discovery Index

Immunological Data Discovery Index

Title:

Chimeric monoclonal antibodies to hypervariable region 1 of hepatitis C virus.

Dataset

identifier:	1329916
description:	epitope description:KGLNGLFDLGPKQKI antigen name:Genome polyprotein host organism:Mus musculus BALB/c antibody name:cAb 15H4
aggregation:	instance of dataset
availability:	available
primaryPublications:	15914849

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1002205
landingPage:	http://www.iedb.org/assay/1329916

Publication

type:	Literature
publicationVenue:	J Gen Virol
dates:	2005

Dimension

study type:	b cell assays
subject species:	Hepatitis C virus

Person

fullName:	Chengyao Li Jean-Pierre Allain

Data Type

method:	surface plasmon resonance (SPR)

Study

name:	Chimeric monoclonal antibodies to hypervariable region 1 of hepatitis C virus.
description:	This 15-mer peptide was derived from the HVR1 of the HCV polyprotein (strain MH2). Seven KLH/BSA conjugated 15-mer HVR1 peptides were tested against HVR1-specific chimeric antibodies (cAb) and standard mAbs for binding affinity. The affinities of cAbs and mAbs (2P24 and 15H4) were similar. Chimeric 15H4 consisted of CDRs from originally immunized mice and the human CK and CH1 (IgG1) constant regions.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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