Synthetic peptide vaccine confers protection against murine malaria. | ImmuneData Discovery Index

Immunological Data Discovery Index

Immunological Data Discovery Index

Title:

Synthetic peptide vaccine confers protection against murine malaria.

Dataset

identifier:	1336570
description:	epitope description:DPPPPNPNDPPPPNPN antigen name:Circumsporozoite (CS) protein, putative host organism:Mus musculus A/J antibody name:anti-17.1-BDB-TT
aggregation:	instance of dataset
availability:	available
primaryPublications:	3316473

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1002519
landingPage:	http://www.iedb.org/assay/1336570

Publication

type:	Literature
publicationVenue:	J Exp Med
dates:	1987

Dimension

study type:	b cell assays
subject species:	Plasmodium berghei

Person

fullName:	F Zavala J P Tam P J Barr P J Romero V Ley R S Nussenzweig V Nussenzweig

Data Type

method:	radio immuno assay (RIA)

Study

name:	Synthetic peptide vaccine confers protection against murine malaria.
description:	The circumsporozoite protein contains multiple tandem repeats of the sequence DPPPPNPN. Mice immunized with the epitope produced antibodies that bound to immobilized P. berghei recombinant circumsporozoite protein. This binding was inhibited by recombinant CS protein. The conjugate of epitope and tetanus toxoid crosslinked with bisdiazobenzidine induced higher titers of antibodies than the conjugate crosslinked with glutaraldehyde.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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