High non-protective, long-lasting antibody levels in malaria are associated with haplotype shifting in MHC-peptide-TCR complex formation: a new mechanism for immune evasion.

Title:

High non-protective, long-lasting antibody levels in malaria are associated with haplotype shifting in MHC-peptide-TCR complex formation: a new mechanism for immune evasion.

Dataset

identifier:	1332711
description:	epitope description:GYSLFQKEMKTLNEGTSGTA host organism:Aotus nancymaae antibody name:Monkey sera
aggregation:	instance of dataset
availability:	available
primaryPublications:	16483708

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1002268
landingPage:	http://www.iedb.org/assay/1332711

Publication

type:	Literature
publicationVenue:	Biochimie
dates:	2006

Dimension

study type:	b cell assays
subject species:

Person

fullName:	Manuel E Patarroyo Adriana Bermú dez Luz Mary Salazar Fabiola Espejo

Data Type

method:	immuno staining

Study

name:	High non-protective, long-lasting antibody levels in malaria are associated with haplotype shifting in MHC-peptide-TCR complex formation: a new mechanism for immune evasion.
description:	Indirect immunofluorescence (IFA) antibody titers were determined by testing the reactivity of immune monkey sera against synchronized late-stage schizonts from a continuous P. falciparum culture. Two of 12 animals reacted by day 15 to this HABP analogue, and 2 had titers by day 20. Western blot analysis identified critical binding residues [M9, K10 and T11]. Cysteine-glycine (CG) was added to the N- and C-termini of each peptide during synthesis to allow polymerization following oxidation.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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