Peptide mapping of conformational epitopes in a human malarial parasite heat shock protein. | ImmuneData Discovery Index

Immunological Data Discovery Index

Immunological Data Discovery Index

Title:

Peptide mapping of conformational epitopes in a human malarial parasite heat shock protein.

Dataset

identifier:	1338859
description:	epitope description:KSSLEDQKIKEKLQP antigen name:Circumsporozoite (CS) protein host organism:Aotus trivirgatus antibody name:immune sera
aggregation:	instance of dataset
availability:	available
primaryPublications:	2471738

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1002688
landingPage:	http://www.iedb.org/assay/1338859

Publication

type:	Literature
publicationVenue:	J Immunol
dates:	1989

Dimension

study type:	b cell assays
subject species:	Plasmodium falciparum

Person

fullName:	S J Richman T S Vedvick R T Reese

Data Type

method:	ELISA

Study

name:	Peptide mapping of conformational epitopes in a human malarial parasite heat shock protein.
description:	The protein is a member of the heat shock protein 70 family. It was deduced that the epitope was recognized by sera from owl monkeys immune to P. falciparum. Sera from 4 of 4 immune monkeys bound to peptide 4, derived from residues 141-204 and which contains the epitope, whereas only 1 of 4 sera bound to peptide 3, derived from residues 156-204 and which does not contain the epitope. Residues 143-154 are predicted to form a hydrophilic helical region in the C7 protein.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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