Immunological Data Discovery Index
Immunological Data Discovery Index
| authorizations: |
registration not required
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| accessURL: |
http://www.iedb.org/reference/1002638 |
| landingPage: |
http://www.iedb.org/assay/1338972 |
| type: |
Literature
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| publicationVenue: |
Infect Immun
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| dates: |
2001
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| study type: | b cell assays |
| subject species: | Plasmodium falciparum |
| fullName: |
R Moreno
F Pö
ltl-Frank
D Stü
ber
H Matile
M Mutz
N A Weiss
G Pluschke
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| method: |
ELISA
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| name: |
Rhoptry-associated protein 1-binding monoclonal antibody raised against a heterologous peptide sequence inhibits Plasmodium falciparum growth in vitro.
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| description: |
This is part of a set of overlapping 15-mer peptides covering the P. falciparum rhoptry-associated protein 1 (RAP-1) sequence from residues 23 to 294.
Epitope mapping analysis was performed in order to identify reactive residues between p191-224 on RAP-1. Synthetic 15-mer peptides spanning the sequence between 23-294 were generated for this analysis. Epitope assignments by peptide mapping were consistent with results obtained by Western blotting with the truncated rRAP-1 molecules. All anti-rRAP-1 p23-711 mAbs showed a parasite growth-accelerating effect, rather than an inhibitory effect.
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| name: |
iedb
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| homePage: |
http://www.iedb.org |
