Synthetic peptide vaccine confers protection against murine malaria. | ImmuneData Discovery Index

Immunological Data Discovery Index

Immunological Data Discovery Index

Title:

Synthetic peptide vaccine confers protection against murine malaria.

Dataset

identifier:	1336572
description:	epitope description:DPPPPNPNDPPPPNPN antigen name:Circumsporozoite (CS) protein, putative host organism:Mus musculus
aggregation:	instance of dataset
availability:	available
primaryPublications:	3316473

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1002519
landingPage:	http://www.iedb.org/assay/1336572

Publication

type:	Literature
publicationVenue:	J Exp Med
dates:	1987

Dimension

study type:	b cell assays
subject species:	Plasmodium berghei

Person

fullName:	F Zavala J P Tam P J Barr P J Romero V Ley R S Nussenzweig V Nussenzweig

Data Type

method:	in vivo assay

Study

name:	Synthetic peptide vaccine confers protection against murine malaria.
description:	The circumsporozoite protein contains multiple tandem repeats of the sequence DPPPPNPN. In two experiments, 87% (7 of 8) and 75% (6 of 8) of mice immunized with the epitope were protected against malaria infection after challenge with 1000 spororzoites (i.v.) 15 days after the last boost. This was comparable to the 85% (6 of 7 mice) protection rate achieved by immunization with irradiated parasites. All naive mice and mice immunized with TT were not protected.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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