Absence of antigenic diversity in Pf155, a major parasite antigen in membranes of erythrocytes infected with Plasmodium falciparum.

Title:

Absence of antigenic diversity in Pf155, a major parasite antigen in membranes of erythrocytes infected with Plasmodium falciparum.

identifier:	1336651
description:	epitope description:EENVEENV antigen name:DNAJ protein, putative host organism:Oryctolagus cuniculus New Zealand White antibody name:anti-(EENV)₂
aggregation:	instance of dataset
availability:	available
primaryPublications:	2448335

study type:	b cell assays
subject species:	Plasmodium falciparum FC27/Papua New Guinea

fullName:	H K Perlmann K Berzins B Wå hlin R Udomsangpetch W Ruangjirachuporn M Wahlgren P H Perlmann

method:	immuno staining

name:	Absence of antigenic diversity in Pf155, a major parasite antigen in membranes of erythrocytes infected with Plasmodium falciparum.
description:	The C-terminal end of the ring-infected erythrocyte surface antigen (RESA Pf155) contains multiple tandem repeats of the sequence EENV. Rabbit antibodies, raised against the epitope, exhibited bright membrane staining of glutaraldehyde-fixed and air-dried monolayers of ring-infected erthrocytes from a Liberian patient, using the erthrocyte membrane immunofluorescence (EMIF) assay. The rabbit antibodies stained ring-infected erthrocytes obtained using 11 different laboratory strains of P. falciparum or clones obtained from infected Aotus monkeys and 26 erythrocyte samples isolated from Liberian (11 of 11), Colombian (9 of 9), and Swedish (6 of 6 infected in West or Central Africa or Asia) patients. The authors conclude that the ring-infected erythrocyte surface antigen Pf155 is antigenically invariant.

name:	iedb
homePage:	http://www.iedb.org

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