Absence of antigenic diversity in Pf155, a major parasite antigen in membranes of erythrocytes infected with Plasmodium falciparum.

Title:

Absence of antigenic diversity in Pf155, a major parasite antigen in membranes of erythrocytes infected with Plasmodium falciparum.

identifier:	1336654
description:	epitope description:EENVEHDA antigen name:DNAJ protein, putative host organism:Mus musculus antibody name:MoMAb anti-EENVEHDA
aggregation:	instance of dataset
availability:	available
primaryPublications:	2448335

study type:	b cell assays
subject species:	Plasmodium falciparum FC27/Papua New Guinea

fullName:	H K Perlmann K Berzins B Wå hlin R Udomsangpetch W Ruangjirachuporn M Wahlgren P H Perlmann

method:	immuno staining

name:	Absence of antigenic diversity in Pf155, a major parasite antigen in membranes of erythrocytes infected with Plasmodium falciparum.
description:	The C-terminal end of the ring-infected erythrocyte surface antigen (RESA Pf155) contains multiple tandem repeats of the epitope. A mouse mAb, raised against the epitope, exhibited bright membrane staining of glutaraldehyde-fixed and air-dried monolayers of ring-infected erthrocytes from a Liberian patient, using the erthrocyte membrane immunofluorescence (EMIF) assay. The MoMAb stained ring-infected erthrocytes obtained using 11 different laboratory strains of P. falciparum or clones obtained from infected Aotus monkeys and 26 erythrocyte samples isolated from Liberian (11 of 11), Colombian (9 of 9), and Swedish (6 of 6 infected in West or Central Africa or Asia) patients. The authors conclude that the ring-infected erythrocyte surface antigen Pf155 is antigenically invariant.

name:	iedb
homePage:	http://www.iedb.org

If you are having problems using our tools, or if you would just like to send us some feedback, please post your questions on Feedback.