Modulation of the humoral response to repeat and non-repeat sequences of the circumsporozoite protein of Plasmodium vivax using novel adjuvant and delivery systems.

Title:

Modulation of the humoral response to repeat and non-repeat sequences of the circumsporozoite protein of Plasmodium vivax using novel adjuvant and delivery systems.

Dataset

identifier:	1336688
description:	epitope description:GDRADGQPAGDRAAGQPA antigen name:Circumsporozoite protein host organism:Mus musculus Swiss antibody name:Mouse sera
aggregation:	instance of dataset
availability:	available
primaryPublications:	11487368

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1002546
landingPage:	http://www.iedb.org/assay/1336688

Publication

type:	Literature
publicationVenue:	Ann Trop Med Parasitol
dates:	2001

Dimension

study type:	b cell assays
subject species:	Plasmodium simium

Person

fullName:	B E Thomas M Manocha W Haq C R Pillai D N Rao

Data Type

method:	ELISA

Study

name:	Modulation of the humoral response to repeat and non-repeat sequences of the circumsporozoite protein of Plasmodium vivax using novel adjuvant and delivery systems.
description:	Peptide-specific IgG was induced in mice immunized with this peptide beta-casein adjuvant. Mouse strain (C56BL/6, BALB/c, CBA/j or Swiss) and type of vaccine formulation (liposome, alum or microsphere) had little effect on the overall peptide-specific titers. Isotypes IgG2a and IgG2b predominated. Immunization with a peptide repeat region induced higher titers than HBP.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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