Inhibitory and blocking monoclonal antibody epitopes on merozoite surface protein 1 of the malaria parasite Plasmodium falciparum.

Title:

Inhibitory and blocking monoclonal antibody epitopes on merozoite surface protein 1 of the malaria parasite Plasmodium falciparum.

identifier:	1337512
description:	epitope description:KQCPENSG antigen name:Merozoite surface protein 1 host organism:Mus musculus antibody name:mAbs 12.8, 12.10, 1E1, and 7.5
aggregation:	instance of dataset
availability:	available
primaryPublications:	11292349

study type:	b cell assays
subject species:	Plasmodium falciparum

fullName:	C Uthaipibull B Aufiero S E Syed B Hansen J A Guevara Patiñ o E Angov I T Ling K Fegeding W D Morgan C Ockenhouse B Birdsall J Feeney J A Lyon A A Holder

method:	ELISA

name:	Inhibitory and blocking monoclonal antibody epitopes on merozoite surface protein 1 of the malaria parasite Plasmodium falciparum.
description:	PEPSCAN analysis was performed to evaluate the binding of mAbs to octapeptides spanning the length of the MSP-1 protein. This peptide was not bound by any of the four mAbs. Site-directed mutagenesis of a GST-MSP-1₁₉ construct revealed critical residues for the binding of each mAbs: 12.8 = E26, R20, E24, K29, L31, K40; mAb 7.5 = N15, Q14, R20, K29, Y34, Q6, E43; mAb 12.10 = Y84 and mAb 1E1 = K40, L31.

name:	iedb
homePage:	http://www.iedb.org

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