Structure of an immunodominant epitope of the circumsporozoite surface protein of Plasmodium knowlesi.

Title:

Structure of an immunodominant epitope of the circumsporozoite surface protein of Plasmodium knowlesi.

identifier:	1337722
description:	epitope description:QAQGDGANAGQPQAQGDGANAGQP antigen name:Circumsporozoite (CS) protein host organism:Mus musculus antibody name:2G3, 5H8, 8B8, 8E11
aggregation:	instance of dataset
availability:	available
primaryPublications:	6210107

study type:	b cell assays
subject species:	Plasmodium knowlesi strain H

fullName:	D H Schlesinger A H Cochrane R W Gwadz G N Godson R Melton R S Nussenzweig V Nussenzweig

method:	antigen inhibition

name:	Structure of an immunodominant epitope of the circumsporozoite surface protein of Plasmodium knowlesi.
description:	The circumsporozoite protein contains multiple tandem repeats of the sequence NAGQPQAQGDGA. The epitope inhibited binding of mAbs 2G3, 5H8, 8B8 and 8E11 to an extract of P. knowlesi sporozoites containing the circumsporozoite protein. The dodecapeptide (QAQGDGANAGQP) containing a single repeat unit was equally effective in inhibiting binding of mAbs 2G3 and 5H8, but did not inhibit mAb 8E11.

name:	iedb
homePage:	http://www.iedb.org

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