Synthetic peptide vaccine confers protection against murine malaria. | ImmuneData Discovery Index

Immunological Data Discovery Index

Immunological Data Discovery Index

Title:

Synthetic peptide vaccine confers protection against murine malaria.

Dataset

identifier:	1337761
description:	epitope description:DPPPPNPNDPPPPNPN antigen name:Circumsporozoite (CS) protein, putative host organism:Mus musculus A/J antibody name:anti-sporozoite
aggregation:	instance of dataset
availability:	available
primaryPublications:	3316473

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1002519
landingPage:	http://www.iedb.org/assay/1337761

Publication

type:	Literature
publicationVenue:	J Exp Med
dates:	1987

Dimension

study type:	b cell assays
subject species:	Plasmodium berghei

Person

fullName:	F Zavala J P Tam P J Barr P J Romero V Ley R S Nussenzweig V Nussenzweig

Data Type

method:	antigen inhibition

Study

name:	Synthetic peptide vaccine confers protection against murine malaria.
description:	The circumsporozoite protein contains multiple tandem repeats of the sequence DPPPPNPN. The epitope inhibited binding of mouse anti-sporozoite sera to P. berghei recombinant circumsporozoite protein. The epitope was approximately 20-fold more effective at inhbition than the peptide DPAPPNAPN)₂D, representing the other main CS repeat sequence.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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