LKM1 autoantibodies in chronic hepatitis C infection: a case of molecular mimicry? | ImmuneData Discovery Index

Immunological Data Discovery Index

Immunological Data Discovery Index

Title:

LKM1 autoantibodies in chronic hepatitis C infection: a case of molecular mimicry?

Dataset

identifier:	1337824
description:	epitope description:SVLTLET host organism:Homo sapiens antibody name:affinity purified anti-HCV+/LKM1+ sera
aggregation:	instance of dataset
availability:	available
primaryPublications:	16037945

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1001773
landingPage:	http://www.iedb.org/assay/1337824

Publication

type:	Literature
publicationVenue:	Hepatology
dates:	2005

Dimension

study type:	b cell assays
subject species:

Person

fullName:	Gabriel Marceau Pascal Lapierre Kathie Bé land Hugo Soudeyns Fernando Alvarez

Data Type

method:	phage display

Study

name:	LKM1 autoantibodies in chronic hepatitis C infection: a case of molecular mimicry?
description:	Anti-liver-kidney microsome type 1 (LKM1) autoantibodies from 3 patients chronically infected by hepatitis C virus were affinity-purified using immobilized CYP2D6 (cytochrome P450 2D6) protein. The affinity-purified antibodies recognized the epitope from a phage display library. The epitope sequence can be aligned with residues 2194-2200 of HCV 1a NS5a protein. The authors suggest that the antibodies recognize cross-reactive conformational epitopes on CYP2D6 and HCV proteins.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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