Immunological Data Discovery Index
Immunological Data Discovery Index
| authorizations: |
registration not required
|
| accessURL: |
http://www.iedb.org/reference/1002640 |
| landingPage: |
http://www.iedb.org/assay/1338086 |
| type: |
Literature
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| publicationVenue: |
Infect Immun
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| dates: |
2000
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| study type: | b cell assays |
| subject species: |
| fullName: |
C Aucan
Y Traoré
F
B Nacro
T Traoré
-Leroux
F Fumoux
P Rihet
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| method: |
ELISA
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| name: |
High immunoglobulin G2 (IgG2) and low IgG4 levels are associated with human resistance to Plasmodium falciparum malaria.
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| description: |
This peptide represents one of five highly conserved B cell epitopes from P. falciparum chosen for this study. The conserved epitope QHGHMHGS was not found in either Swissprot or GenBank with the N-terminal AAA as the authors have synthesized it.
IgG directed against RESA, MSP-1 and MSP-2 peptides were detected in all of the individuals. Most of the individuals had all IgG subclasses (IgG1, IgG2, IgG3 and IgG4) directed to the RESA, MSP-1 and MSP-2 epitopes. Epitope-specific IgG was found to be positively correlated with age. Anti-epitope antibodies increased between the dry (P1) and wet (P2) seasons and were found to be higher (IgG3 and IgG2 in particular) in individuals protected from malaria attack. IgG4 was found to correlate with risk of malaria attack.
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| name: |
iedb
|
| homePage: |
http://www.iedb.org |
