Fixed, epitope-specific, cytophilic antibody response to the polymorphic block 2 domain of the Plasmodium falciparum merozoite surface antigen MSP-1 in humans living in a malaria-endemic area.

Title:

Fixed, epitope-specific, cytophilic antibody response to the polymorphic block 2 domain of the Plasmodium falciparum merozoite surface antigen MSP-1 in humans living in a malaria-endemic area.

Dataset

identifier:	1338316
description:	epitope description:TSGTSGTSGTSGTSG antigen name:Merozoite surface protein 1 host organism:Homo sapiens
aggregation:	instance of dataset
availability:	available
primaryPublications:	11180119

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1002620
landingPage:	http://www.iedb.org/assay/1338316

Publication

type:	Literature
publicationVenue:	Eur J Immunol
dates:	2001

Dimension

study type:	b cell assays
subject species:	Plasmodium falciparum Palo Alto/Uganda

Person

fullName:	H Jouin C Rogier J F Trape O Mercereau-Puijalon

Data Type

method:	ELISA

Study

name:	Fixed, epitope-specific, cytophilic antibody response to the polymorphic block 2 domain of the Plasmodium falciparum merozoite surface antigen MSP-1 in humans living in a malaria-endemic area.
description:	Antibodies from each individual recognized limited number of peptides with restricted allelic specificity, and no or few variants. This pattern was unrelated to the allelic types of previous, ongoing or subsequent infecting parasites for all 5 subjects tested over 15-month period. Nine out of 10 positive plasma contained an exclusive IgG3 isotype.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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