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Title: Construction of a synthetic immunogen: use of the natural immunomodulator polytuftsin in malaria vaccines against RESA antigen of Plasmodium falciparum.
identifier: 1343467
description:
epitope description:EENVEHDAEENVEHDA
antigen name:DNAJ protein, putative
host organism:Mus musculus
aggregation:
instance of dataset
availability:
available
primaryPublications: 7526572
authorizations:
registration not required
accessURL: http://www.iedb.org/reference/1002983
landingPage: http://www.iedb.org/assay/1343467
type:
Literature
publicationVenue:
Vaccine
dates:
1994
study type: b cell assays
subject species: Plasmodium falciparum
fullName:
K Pawan
B B Ivanov
L Kabilan
D N Rao
method:
biological activity
name:
Construction of a synthetic immunogen: use of the natural immunomodulator polytuftsin in malaria vaccines against RESA antigen of Plasmodium falciparum.
description:
Sera from mice immunized with the epitope, the epitope and polytuftsin, or peptide conjugates consisting of 6-8 copies of the epitope linked to polytuftsin inhibited merozoite reinvasion in all mice strains tested (H-2a, H-2b, H-2d, H-2i, and H-2k). Immunization with epitope conjugates resulted increased responses as compared to immunization with the epitope alone.

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