Epitope-specific humoral immunity to Plasmodium vivax Duffy binding protein. | ImmuneData Discovery Index

Immunological Data Discovery Index

Immunological Data Discovery Index

Title:

Epitope-specific humoral immunity to Plasmodium vivax Duffy binding protein.

Dataset

identifier:	1343140
description:	epitope description:VNNTDTNFHSDITFR antigen name:Duffy receptor host organism:Homo sapiens
aggregation:	instance of dataset
availability:	available
primaryPublications:	12704122

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1002765
landingPage:	http://www.iedb.org/assay/1343140

Publication

type:	Literature
publicationVenue:	Infect Immun
dates:	2003

Dimension

study type:	b cell assays
subject species:	Plasmodium vivax

Person

fullName:	Jia Xainli Jennifer L Cole-Tobian Moses Baisor Will Kastens Moses Bockarie Syed Shams Yazdani Chetan E Chitnis John H Adams Christopher L King

Data Type

method:	ELISA

Study

name:	Epitope-specific humoral immunity to Plasmodium vivax Duffy binding protein.
description:	Natural polymorphism is found at position 10 of this peptide. This region has been previously identified as containing a T cell epitope. Sera samples from P.vivax exposed individuals were affinity purified towards this peptide and analyzed for reactivity to the cognate peptide and the natural variant peptide 308R. Similar levels of recognition are obtained for both peptides. Direct ELISA from whole serum of individuals recognizing this peptide showed that 56 reacted also to the variant peptide. For 9 individuals with differential recognition of the 2 peptides, 3 had significant preferential recognition of the cognate peptide.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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