Rationale for development of a synthetic vaccine against Plasmodium falciparum malaria. | ImmuneData Discovery Index

Immunological Data Discovery Index

Immunological Data Discovery Index

Title:

Rationale for development of a synthetic vaccine against Plasmodium falciparum malaria.

Dataset

identifier:	1339904
description:	epitope description:NANPNANPNANP antigen name:Circumsporozoite (CS) protein host organism:Homo sapiens antibody name:human sera
aggregation:	instance of dataset
availability:	available
primaryPublications:	2409595

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1002736
landingPage:	http://www.iedb.org/assay/1339904

Publication

type:	Literature
publicationVenue:	Science
dates:	1985

Dimension

study type:	b cell assays
subject species:	Plasmodium falciparum

Person

fullName:	F Zavala J P Tam M R Hollingdale A H Cochrane I Quakyi R S Nussenzweig V Nussenzweig

Data Type

method:	radio immuno assay (RIA)

Study

name:	Rationale for development of a synthetic vaccine against Plasmodium falciparum malaria.
description:	The circumsporozoite protein contains multiple tandem repeats of the sequence NANP. Sera from donors living in the malaria-endemic area of The Gambia, Africa reacted with the epitope. The percentage of positive sera increased with age, from 21% in donors 1-14 years to 85% in adults > 34 years. The epitope inhibited binding of the positive sera to glutaraldehyde-fixed sporozoites, as detected by indirect immunofluorescence.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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