Rapid onset of malaria-induced mortality by immunizations with lipo-peptides: an experimental model to study deleterious immune responses and immunopathology in malaria.

Title:

Rapid onset of malaria-induced mortality by immunizations with lipo-peptides: an experimental model to study deleterious immune responses and immunopathology in malaria.

Dataset

identifier:	1340449
description:	epitope description:PPPPNPNDPPPPNPND antigen name:Circumsporozoite (CS) protein, putative host organism:Mus musculus
aggregation:	instance of dataset
availability:	available
primaryPublications:	9041668

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1002787
landingPage:	http://www.iedb.org/assay/1340449

Publication

type:	Literature
publicationVenue:	Vaccine
dates:	1997

Dimension

study type:	b cell assays
subject species:	Plasmodium berghei

Person

fullName:	R C Reed A F Verhuel R L Hunter V Udhayakumar V Louis-Wileman V J Jennings D L Jue R M Wohlhueter A A Lal

Data Type

method:	in vivo assay

Study

name:	Rapid onset of malaria-induced mortality by immunizations with lipo-peptides: an experimental model to study deleterious immune responses and immunopathology in malaria.
description:	Mice immunized with the epitope alone were not protected from challenge with the source species (P. berghei sporozoites). Mice immunized with a peptide containing both the epitope and a T cell epitope (KQJRDSITEEWS) were protected (with use of a specific regimen/dose...using other regimens/doses did not result in protection and sometimes even accelerated mortality).

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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