Plasmodium falciparum polyoximes: highly immunogenic synthetic vaccines constructed by chemoselective ligation of repeat B-cell epitopes and a universal T-cell epitope of CS protein.

Title:

Plasmodium falciparum polyoximes: highly immunogenic synthetic vaccines constructed by chemoselective ligation of repeat B-cell epitopes and a universal T-cell epitope of CS protein.

Dataset

identifier:	1341009
description:	epitope description:DPNANPNVDPNANPNVNANPNANPNANP host organism:Mus musculus A/J antibody name:Mouse sera
aggregation:	instance of dataset
availability:	available
primaryPublications:	9569470

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1002850
landingPage:	http://www.iedb.org/assay/1341009

Publication

type:	Literature
publicationVenue:	Vaccine
dates:	1998

Dimension

study type:	b cell assays
subject species:

Person

fullName:	E H Nardin J M Calvo-Calle G A Oliveira P Clavijo R Nussenzweig R Simon W Zeng K Rose

Data Type

method:	immuno staining

Study

name:	Plasmodium falciparum polyoximes: highly immunogenic synthetic vaccines constructed by chemoselective ligation of repeat B-cell epitopes and a universal T-cell epitope of CS protein.
description:	The CSP B repeat epitopes were combined in tetrabranched, di- and tri-epitope constructs with and without a T-helper epitope. The combined peptide sequence was derived from the CS protein of P. falciparum (NF54). While immunization with the di- and tri-epitope polyoxime vaccines in Pam3Cys elicited reactivity to P. falciparum sporozoites as measured by immunofluorescence assay (IFA), the tri-epitope formulation gave a better correlation between ELISA titer and IFA reactivity.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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