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Title: Modifying RESA protein peptide 6671 to fit into HLA-DRbeta1* pockets induces protection against malaria.
identifier: 1341537
description:
epitope description:MTDVIRFRYSNNYEASDH
host organism:Aotus nancymaae
antibody name:Monkey sera
aggregation:
instance of dataset
availability:
available
primaryPublications: 14985134
authorizations:
registration not required
accessURL: http://www.iedb.org/reference/1002891
landingPage: http://www.iedb.org/assay/1341537
type:
Literature
publicationVenue:
Biochem Biophys Res Commun
dates:
2004
study type: b cell assays
subject species:
fullName:
Martha Patricia Alba
Luz Mary Salazar
Luis Eduardo Vargas
Mary Trujillo
Yolanda Lopez
Manuel Elkin Patarroyo
method:
in vivo assay
name:
Modifying RESA protein peptide 6671 to fit into HLA-DRbeta1* pockets induces protection against malaria.
description:
This peptide is an analog of the RESA HABP epitope MTDVNRYRYSNNYEAIPHIS (aa141-160), which has been identified as an important erythrocyte-binding protein in the process of P. falciparum merozoite invasion of RBCs.
Immunization of monkeys with the epitope failed to generate protection against live challenge with P. falciparum. Protection was defined as the absence of parasitemia 15 days post-challenge.

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