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Title: Modifying RESA protein peptide 6671 to fit into HLA-DRbeta1* pockets induces protection against malaria.
identifier: 1341551
description:
epitope description:MTDVIRYRYSNNYESNPHIS
host organism:Aotus nancymaae
antibody name:Monkey sera
aggregation:
instance of dataset
availability:
available
primaryPublications: 14985134
authorizations:
registration not required
accessURL: http://www.iedb.org/reference/1002891
landingPage: http://www.iedb.org/assay/1341551
type:
Literature
publicationVenue:
Biochem Biophys Res Commun
dates:
2004
study type: b cell assays
subject species:
fullName:
Martha Patricia Alba
Luz Mary Salazar
Luis Eduardo Vargas
Mary Trujillo
Yolanda Lopez
Manuel Elkin Patarroyo
method:
immuno staining
name:
Modifying RESA protein peptide 6671 to fit into HLA-DRbeta1* pockets induces protection against malaria.
description:
This peptide is an analog of the RESA HABP epitope MTDVNRYRYSNNYEAIPHIS (aa141-160), which has been identified as an important erythrocyte-binding protein in the process of P. falciparum merozoite invasion of RBCs.
Monkeys immunized with the epitope failed to generate P. falciparum ring stage-specific antibodies as measured by immunofluroescence assay (IFA).

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