Antibodies to malaria peptide mimics inhibit Plasmodium falciparum invasion of erythrocytes. | ImmuneData Discovery Index

Immunological Data Discovery Index

Immunological Data Discovery Index

Title:

Antibodies to malaria peptide mimics inhibit Plasmodium falciparum invasion of erythrocytes.

Dataset

identifier:	1341723
description:	epitope description:IPSTAFTDIAWVRLPNHY host organism:Homo sapiens
aggregation:	instance of dataset
availability:	available
primaryPublications:	14742560

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1002888
landingPage:	http://www.iedb.org/assay/1341723

Publication

type:	Literature
publicationVenue:	Infect Immun
dates:	2004

Dimension

study type:	b cell assays
subject species:

Person

fullName:	Joanne L Casey Andrew M Coley Robin F Anders Vince J Murphy Karen S Humberstone Alan W Thomas Michael Foley

Data Type

method:	biological activity

Study

name:	Antibodies to malaria peptide mimics inhibit Plasmodium falciparum invasion of erythrocytes.
description:	This peptide is derived from a random peptide library. It mimics a conformational epitope on P.falciparum AMA-1 protein, recognized by the inhibitory rat mAb 4G2dc1. The library was constructed with random peptides fused to the N-terminus of protein III of phage M13. Peptide specific Abs affinity purified from malaria exposed-donors sera are able to stain the merozoite apical organelle in immunofluorescence studies of infected RBCs, and to inhibit merozoite invasion of RBCs significantly (41% inhibition, compared to non-immune IgG).

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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