Development of two monoclonal antibodies against Plasmodium falciparum sporozoite surface protein 2 and mapping of B-cell epitopes.

Title:

Development of two monoclonal antibodies against Plasmodium falciparum sporozoite surface protein 2 and mapping of B-cell epitopes.

identifier:	1342373
description:	epitope description:DRYIPYSP antigen name:Thrombospondin-related anonymous protein, TRAP host organism:Homo sapiens
aggregation:	instance of dataset
availability:	available
primaryPublications:	9234808

study type:	b cell assays
subject species:	Plasmodium falciparum

fullName:	Y Charoenvit V Fallarme W O Rogers J B Sacci Jr M Kaur J C Aguiar L F Yuan G Corradin E Andersen B Wizel R A Houghten A Oloo P De la Vega S L Hoffman

method:	ELISA

name:	Development of two monoclonal antibodies against Plasmodium falciparum sporozoite surface protein 2 and mapping of B-cell epitopes.
description:	This sequence is deduced from epitope mapping studies with overlapping peptides to harbor a minimal region for mAb recognition between residues 425-428. Peptide ELISA was performed to test the recognition of this sequence (as a tandem repeat of 3 copies) by serum of donors from malaria endemic areas (Indonesia and Kenya). 12/38 Indonesians and 9/33 Kenyan reacted with the peptide, most at low levels, except a Kenyan subject, who had a high reactivity to this peptide. These results demonstrate that humans living in P.falciparum malaria-endemic areas develop an antibody response to this epitope. .

name:	iedb
homePage:	http://www.iedb.org

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