Development of two monoclonal antibodies against Plasmodium falciparum sporozoite surface protein 2 and mapping of B-cell epitopes.

Title:

Development of two monoclonal antibodies against Plasmodium falciparum sporozoite surface protein 2 and mapping of B-cell epitopes.

identifier:	1342496
description:	epitope description:CHPSDGKCN antigen name:Thrombospondin-related anonymous protein, TRAP host organism:Mus musculus
aggregation:	instance of dataset
availability:	available
primaryPublications:	9234808

study type:	b cell assays
subject species:	Plasmodium falciparum

fullName:	Y Charoenvit V Fallarme W O Rogers J B Sacci Jr M Kaur J C Aguiar L F Yuan G Corradin E Andersen B Wizel R A Houghten A Oloo P De la Vega S L Hoffman

method:	ELISA

name:	Development of two monoclonal antibodies against Plasmodium falciparum sporozoite surface protein 2 and mapping of B-cell epitopes.
description:	From epitope mapping studies with overlapping peptides, it was deduced that a minimal region for mAb recognition is located between residues 206-212. Three inbred (BALB/c ByJ, A/J, C57BL/6) and one outbred (CD1) strains of mice were immunized with a MAP containing a tandem repeat of 3 copies of CHPSDGKCN, and all develop high titers towards a peptide made of a tandem of 2 copies of it. .

name:	iedb
homePage:	http://www.iedb.org

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