Development of two monoclonal antibodies against Plasmodium falciparum sporozoite surface protein 2 and mapping of B-cell epitopes.

Title:

Development of two monoclonal antibodies against Plasmodium falciparum sporozoite surface protein 2 and mapping of B-cell epitopes.

identifier:	1342498
description:	epitope description:CHPSDGKCN antigen name:Thrombospondin-related anonymous protein, TRAP host organism:Mus musculus antibody name:PfSSP2.2
aggregation:	instance of dataset
availability:	available
primaryPublications:	9234808

study type:	b cell assays
subject species:	Plasmodium falciparum

fullName:	Y Charoenvit V Fallarme W O Rogers J B Sacci Jr M Kaur J C Aguiar L F Yuan G Corradin E Andersen B Wizel R A Houghten A Oloo P De la Vega S L Hoffman

method:	ELISA

name:	Development of two monoclonal antibodies against Plasmodium falciparum sporozoite surface protein 2 and mapping of B-cell epitopes.
description:	From epitope mapping studies with overlapping peptides, it was deduced that a minimal region for mAb recognition is located between residues 206-212. Peptide ELISA was performed to map the minimal epitope for mAb pfSSP2.2, and HPSDGKC was obtained as the residues in all the overlapping peptides with positive results.

name:	iedb
homePage:	http://www.iedb.org

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