Development of two monoclonal antibodies against Plasmodium falciparum sporozoite surface protein 2 and mapping of B-cell epitopes.

Title:

Development of two monoclonal antibodies against Plasmodium falciparum sporozoite surface protein 2 and mapping of B-cell epitopes.

identifier:	1342508
description:	epitope description:DRYIPYSP antigen name:Thrombospondin-related anonymous protein, TRAP host organism:Mus musculus
aggregation:	instance of dataset
availability:	available
primaryPublications:	9234808

study type:	b cell assays
subject species:	Plasmodium falciparum

fullName:	Y Charoenvit V Fallarme W O Rogers J B Sacci Jr M Kaur J C Aguiar L F Yuan G Corradin E Andersen B Wizel R A Houghten A Oloo P De la Vega S L Hoffman

method:	ELISA

name:	Development of two monoclonal antibodies against Plasmodium falciparum sporozoite surface protein 2 and mapping of B-cell epitopes.
description:	This sequence is deduced from epitope mapping studies with overlapping peptides to harbor a minimal region for mAb recognition between residues 425-428. C57BL/6 were immunized with vaccinia virus expressing full-length PfSSP2 (either i.d. or i.p.) and 2/3 of each route developed high Ab reactivity a peptide made of a tandem of 3 copies of this epitope. .

name:	iedb
homePage:	http://www.iedb.org

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