MHC and malaria: the relationship between HLA class II alleles and immune responses to Plasmodium falciparum.

Title:

MHC and malaria: the relationship between HLA class II alleles and immune responses to Plasmodium falciparum.

identifier:	1343526
description:	epitope description:EENVEENVEENVEENVEENVEENV antigen name:DNAJ protein, putative host organism:Homo sapiens antibody name:human immune sera
aggregation:	instance of dataset
availability:	available
primaryPublications:	1390436

study type:	b cell assays
subject species:	Plasmodium falciparum

fullName:	E M Riley O Olerup S Bennett P Rowe S J Allen M J Blackman M A A Holder B M Greenwood

method:	ELISA

name:	MHC and malaria: the relationship between HLA class II alleles and immune responses to Plasmodium falciparum.
description:	The ring-infected erythrocyte surface antigen (Pf155/RESA) contains multiple tandem repeats of the sequence EENV. There was a statistically significant (P< 0.001) overall association between HLA class II phenotype in the study group A and the antibody level to the epitope. An increased antibody response was associated with RFLP-defined haplotypes 12 (associated with serological specificities DR4 and DQw2) and 15 (associated with serological specificities DR7 and DQw2). The associations were statistically significant, (P< 0.01) and (P< 0.001), respectively, after adjusting for the effects of multiple comparisons. There was a statistically significant (P< 0.0001) difference in the frequency of children responding to the epitope between those with a particular haplotype (RFLP pattern) associated with DQw2 (25.2% responders) and those with other haplotypes associated with DQw2 (7.7% responders).

name:	iedb
homePage:	http://www.iedb.org

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