Chemically synthesized peptides of hepatitis B surface antigen duplicate the d/y specificities and induce subtype-specific antibodies in chimpanzees.

Title:

Chemically synthesized peptides of hepatitis B surface antigen duplicate the d/y specificities and induce subtype-specific antibodies in chimpanzees.

Dataset

identifier:	1346758
description:	epitope description:FPGSSTTSTGPCRTCMTTAQGTSMYPSC antigen name:Large envelope protein host organism:Pan troglodytes antibody name:Chimpanzee sera
aggregation:	instance of dataset
availability:	available
primaryPublications:	6188163

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1003070
landingPage:	http://www.iedb.org/assay/1346758

Publication

type:	Literature
publicationVenue:	Proc Natl Acad Sci U S A
dates:	1983

Dimension

study type:	b cell assays
subject species:	Hepatitis B virus

Person

fullName:	J L Gerin H Alexander J W Shih R H Purcell G Dapolito R Engle N Green J G Sutcliffe T M Shinnick R A Lerner

Data Type

method:	radio immuno assay (RIA)

Study

name:	Chemically synthesized peptides of hepatitis B surface antigen duplicate the d/y specificities and induce subtype-specific antibodies in chimpanzees.
description:	Chimpanzees immunized with the epitope, peptide 49, conjugated to KLH generated a brisk primary and secondary response to HBsAg. While all three animals showed anti-HBsAg reactivity, the one receiving the vaccine in incomplete Freund's showed the highest response (as compared to alum or alum/pertussis). All anti-HBsAg titers decayed with time and subsequent boosts only induced low-level, transient responses.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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