Serum antibodies from malaria-exposed people recognize conserved epitopes formed by the two epidermal growth factor motifs of MSP1(19), the carboxy-terminal fragment of the major merozoite surface protein of Plasmodium falciparum.

Title:

Dataset

identifier:	1345659
description:	epitope description:NISQHQCVKKQCPQNSGCFRHLDEREECKCLLNYKQEGDKCVENPNPT antigen name:Merozoite surface protein 1 host organism:Homo sapiens
aggregation:	instance of dataset
availability:	available
primaryPublications:	7822010

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1002945
landingPage:	http://www.iedb.org/assay/1345659

Publication

type:	Literature
publicationVenue:	Infect Immun
dates:	1995

Dimension

study type:	b cell assays
subject species:	Plasmodium falciparum isolate WELLCOME

Person

fullName:	A F Egan J A Chappel P A Burghaus J S Morris J S McBride A A Holder D C Kaslow E M Riley

Data Type

method:	ELISA

Study

name:	Serum antibodies from malaria-exposed people recognize conserved epitopes formed by the two epidermal growth factor motifs of MSP1(19), the carboxy-terminal fragment of the major merozoite surface protein of Plasmodium falciparum.
description:	This is the EGF-like domain 1 of the MSP1 protein (19kDa fragment). Donors from Gambia were shown to recognize this fragment in ELISA. The level of recongition of the complete 19-kDa fragment increased with age, but no such correlation could be detected for this domain. Reactivity was dependent on the intact disulfide bonds, since the reduced domain was not significantly recognized in 3/3 EGF1 reactive sera. Isotype analysis demonstrated that the predominant antibody response is IgG1.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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