In human malaria protective antibodies are directed mainly against the Lys-Glu ion pair within the Lys-Glu-Lys motif of the synthetic vaccine SPf 66.

Title:

In human malaria protective antibodies are directed mainly against the Lys-Glu ion pair within the Lys-Glu-Lys motif of the synthetic vaccine SPf 66.

Dataset

identifier:	1349307
description:	epitope description:VDYLEEKTKDQDL antigen name:Rhoptry-associated protein 1, RAP1 host organism:Homo sapiens
aggregation:	instance of dataset
availability:	available
primaryPublications:	1557226

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1002783
landingPage:	http://www.iedb.org/assay/1349307

Publication

type:	Literature
publicationVenue:	Parasite Immunol
dates:	1992

Dimension

study type:	b cell assays
subject species:	Plasmodium falciparum

Person

fullName:	A Molano C Segura F Guzman D Lozada M E Patarroyo

Data Type

method:	antigen inhibition

Study

name:	In human malaria protective antibodies are directed mainly against the Lys-Glu ion pair within the Lys-Glu-Lys motif of the synthetic vaccine SPf 66.
description:	Sera from individuals immunized with the synthetic malaria vaccine, SPf66, did not recognize the epitope by ELISA. However, substitutions in the epitope of the first E with K (VDYLKEKTKDQDL) or T with E (VDYLEEKEKDQDL) resulted in recognition suggesting that the KEK motif is important for antibody binding.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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