De novo design of peptide immunogens that mimic the coiled coil region of human T-cell leukemia virus type-1 glycoprotein 21 transmembrane subunit for induction of native protein reactive neutralizing antibodies.

Title:

Dataset

identifier:	1348949
description:	epitope description:LHEVDKDISQLTQAIVKNHKNLLKIAQY + ACET(L1) antigen name:Envelope glycoprotein gp62 host organism:Mus musculus ICR
aggregation:	instance of dataset
availability:	available
primaryPublications:	15060075

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1003131
landingPage:	http://www.iedb.org/assay/1348949

Publication

type:	Literature
publicationVenue:	J Biol Chem
dates:	2004

Dimension

study type:	b cell assays
subject species:	Human T-lymphotropic virus 1

Person

fullName:	Roshni Sundaram Marcus P Lynch Sharad V Rawale Yiping Sun Mirdad Kazanji Pravin T P Kaumaya

Data Type

method:	antigen inhibition

Study

name:	De novo design of peptide immunogens that mimic the coiled coil region of human T-cell leukemia virus type-1 glycoprotein 21 transmembrane subunit for induction of native protein reactive neutralizing antibodies.
description:	This peptide was chosen as it corresponds to the central region of the coiled coil segment of GP21 trasmembrane subunit and is involved in the fusion of viral and cellular membranes and syncytia formation between infected cells. When used as an isolated peptide, the C-terminus was also amidated. Mouse antisera was raised to a construct where this peptide is linked in a 3meric form to facilitate the interaction into a native coiled-coil structure. The antisera recongition of the immunogen is inhibited by the isolated peptide in competition ELISA.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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