Immunological Data Discovery Index
Immunological Data Discovery Index
| Title: | Location and chemical synthesis of a pre-S gene coded immunodominant epitope of hepatitis B virus. |
| authorizations: |
registration not required
|
| accessURL: |
http://www.iedb.org/reference/1003136 |
| landingPage: |
http://www.iedb.org/assay/1349164 |
| type: |
Literature
|
| publicationVenue: |
Science
|
| dates: |
1984
|
| study type: | b cell assays |
| subject species: | Hepatitis B virus subtype adw |
| fullName: |
A R Neurath
S B Kent
N Strick
|
| method: |
radio immuno assay (RIA)
|
| name: |
Location and chemical synthesis of a pre-S gene coded immunodominant epitope of hepatitis B virus.
|
| description: |
The location of the antigenic determinant was predicted using hydrophilicity analysis of the entire pre-S amino acid sequence to be within residues 120-145. RIA demonstrated that sera from rabbits immunized with the epitope generated both peptide- and HBsAg-specific antibodies. Titers increased 4-fold every 2 weeks between week 2 and 8. A Cys residue was added to the C-terminus of the epitope for the purpose of coupling carrier molecules.
|
| name: |
iedb
|
| homePage: |
http://www.iedb.org |