Immunological Data Discovery Index
Immunological Data Discovery Index
| authorizations: |
registration not required
|
| accessURL: |
http://www.iedb.org/reference/1002780 |
| landingPage: |
http://www.iedb.org/assay/1346900 |
| type: |
Literature
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| publicationVenue: |
Ann Trop Med Parasitol
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| dates: |
1998
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| study type: | b cell assays |
| subject species: | Plasmodium vivax |
| fullName: |
M Aré
valo-Herrera
M A Roggero
J M Gonzalez
J Vergara
G Corradin
J A Ló
pez
S Herrera
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| method: |
ELISA
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| name: |
Mapping and comparison of the B-cell epitopes recognized on the Plasmodium vivax circumsporozoite protein by immune Colombians and immunized Aotus monkeys.
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| description: |
Sera from 9 of 20 donors, from a malaria-endemic region of the Colombian Pacific coast, that had antibodies to P. vivax sporozoites reacted with the epitope. Sera from 33 of 65 donors from the community of Zacarias had antibodies to the epitope. In this group, 41 had antibodies to the C-terminal region (residues 301-372) of the circumsporozoite protein, which contains the epitope. No sera (0 of 56) from donors from the community of Bajo Calima had antibodies to the epitope and only one serum in this group, had antibodies to the C-terminal region (residues 301-372). Based on reactivity of overlapping peptides spanning the N- and C-terminal regions outside the central repeat region of the CS protein, the authors conclude that the epitope sequence contains an immunodominant epitope.
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| name: |
iedb
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| homePage: |
http://www.iedb.org |
