Secondary structure and immunogenicity of hybrid synthetic peptides derived from two Plasmodium falciparum pre-erythrocytic antigens.

Title:

Secondary structure and immunogenicity of hybrid synthetic peptides derived from two Plasmodium falciparum pre-erythrocytic antigens.

identifier:	1347181
description:	epitope description:PSDKHIEQYLKKIENSIS antigen name:Circumsporozoite (CS) protein host organism:Mus musculus DBA/2
aggregation:	instance of dataset
availability:	available
primaryPublications:	2143519

study type:	b cell assays
subject species:	Plasmodium falciparum

fullName:	J A Londoñ o H Gras-Masse C Dubeaux A P Druilhe

method:	ELISA

name:	Secondary structure and immunogenicity of hybrid synthetic peptides derived from two Plasmodium falciparum pre-erythrocytic antigens.
description:	While the manuscript reports that this epitope occurs in Plasmodium falciparum circumsporozoite protein (PfCSP), no exact match is returned with a BLAST search. Instead the sequence PSDKHIEQYLKKIKNSIS is what occurs in residues 326-343 of PfCSP (note the K to E switch at position 339). Sera from mice immunized with a peptide that contains the epitope did not recognize the epitope by ELISA.

name:	iedb
homePage:	http://www.iedb.org

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