Two distinct but overlapping antibody binding sites in the pre-S(2) region of HBsAg localized within 11 continuous residues.

Title:

Two distinct but overlapping antibody binding sites in the pre-S(2) region of HBsAg localized within 11 continuous residues.

identifier:	1347618
description:	epitope description:DPRVRGLYFPA antigen name:Large envelope protein host organism:Mus musculus BALB/c antibody name:5520, 5521 and 5535
aggregation:	instance of dataset
availability:	available
primaryPublications:	2428872

study type:	b cell assays
subject species:	Hepatitis B virus subtype ayw

fullName:	D R Milich A McLachlan F V Chisari T Nakamura G B Thornton

method:	radio immuno assay (RIA)

name:	Two distinct but overlapping antibody binding sites in the pre-S(2) region of HBsAg localized within 11 continuous residues.
description:	Fine specificity analysis identified the epitope, a region of 11 continuous residues in the pre-S(2) region of HBsAg to which the murine monoclonal antibody responses were focused [subtypes ayw and adw]. This larger region consists of two distinct overlapping epitopes, p133-139 and p137-143 defined by different fine specifity of the mAbs.

name:	iedb
homePage:	http://www.iedb.org

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