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Title: A general strategy to identify mimotopes of pathological antigens using only random peptide libraries and human sera.
identifier: 1349508
description:
epitope description:CGPFFLAASVC
host organism:Homo sapiens
aggregation:
instance of dataset
availability:
available
primaryPublications: 7514533
authorizations:
registration not required
accessURL: http://www.iedb.org/reference/1003174
landingPage: http://www.iedb.org/assay/1349508
type:
Literature
publicationVenue:
EMBO J
dates:
1994
study type: b cell assays
subject species:
fullName:
A Folgori
R
A Meola
F Felici
G Galfré
R Cortese
P Monaci
A Nicosia
method:
phage display
name:
A general strategy to identify mimotopes of pathological antigens using only random peptide libraries and human sera.
description:
Sera from individuals vaccinized with Hepatitis B virus surface antigen (HBSAg) recognized a phage that displayed the epitope. Specificity of antibody recognition was demonstrated by competition ELISA with the epitope as both surface-bound antigen and free competitor for serum antibodies. Binding of the epitope to serun antibodies was also inhibited by two homologous phage peptides: CGPFYLSAPQC and CGPFFLSPTSC.

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